Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. This means it could potentially alter the levels of those medications in the body. Yes, Calcium D Glucarate is commonly used to help manage estrogen dominance. Can Calcium D Glucarate help with estrogen dominance? No, Calcium D Glucarate does not directly lower testosterone levels. The liver processes estradiol through Phase 1 hydroxylation (producing 2-OH, 4-OH, and 16-OH estrogen metabolites), Phase 2 conjugation (methylation, glucuronidation, sulfation), and Phase 3 excretion through bile. The result is estrogen's proliferative effects on target tissues unopposed by its normal regulatory counter. The DUTCH complete urine test, which maps estrogen metabolite pathways through the liver, provides the mechanistic picture that a single serum estradiol value cannot. A woman with low estradiol and even lower progesterone can be estrogen dominant by ratio. Estrogen dominance is a state of relative estrogen excess in relation to progesterone. If you have a fast COMT variant, you clear dopamine rapidly. It’s what makes you want things, what drives reward-seeking behavior, what creates sexual desire. Others with low aromatase feel more like they have testosterone floating around but nothing is happening with it. Some women with high aromatase feel bloated, moody, and irritable on top of having no libido. You’re not interested in your partner sexually. While CDG does not directly lower testosterone, its effect on estrogen levels is noteworthy. This pathway is responsible for eliminating various toxins, hormones (like estrogen), and other waste products from the body. For men, calcium D-glucarate may help to keep a health balance of estrogen and testosterone. Calcium D-glucarate inhibits beta-glucuronidase, a liver enzyme that slows down the removal of hormones from the body. Calcium D-glucarate helps the liver detoxify certain carcinogens and hormones from the body. A deeper discussion of enterohepatic recirculation can be saved for a future article, but it has been shown to lead, for example, to higher estrogen levels, which in turn increases the risk for breast cancer. You literally can’t feel motivation or reward, including sexual reward, because your dopamine system is desensitized. COMT is an enzyme that breaks down dopamine once it’s been used. Estrogen in excess actually suppresses dopamine, the brain chemical that drives sexual desire. In women, this is actually where most estrogen comes from, especially after menopause when the ovaries stop producing it. One common misconception is that Calcium D Glucarate is a direct testosterone booster. CDG reduces the activity of beta-glucuronidase, thus promoting the excretion of glucuronidated substances. The primary mechanism of action of Calcium D Glucarate centers around beta-glucuronidase, an enzyme produced by gut bacteria. It’s also produced in small amounts by the human body. Andrew Bennett enjoys exploring health and fitness through his personal workouts, as well as researching the latest about the subject. Estrogen can negatively influence prostate health by enlarging the prostate gland, causing benign prostate hyperplasia (BPH) or even prostate cancer. In addition, it may also improve breast health, decreasing the risk of breast cancer.
